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Concomitantly, selective degeneration of nigrostriatal dopaminergic neurons results in severe dopamine depletion within the basal ganglia circuitry [12, 13]

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Epithelial-to-mesenchymal transition EMT is a hallmark of oncogenesis characterized by loss of adhesion structures such as adherens junctions, tight junctions and desmosomes, and enhanced expression of α-smooth muscle actin, fibronectin, vimentin and other proteins necessary for migration and invasion