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The vascular endothelium and cavernosal arteries are a source of vasorelaxing factors such as NO, prostaglandin I2, endothelium-derived hyperpolarizing factor (EDHF), the vasoconstrictor factors such as angiotensin II (Ang II) and endothelin-1 (ET-1), cell adhesion molecules such as Intercellular Cell Adhesion Molecule-1 (ICAM-1) and Vascular Cell Adhesion Molecule-1 (VCAM-1), growth factors such as vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF), inflammatory factors, etc
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Mitragynine and speciofoline showed similar inhibitory effects towards CYP2C9 and CYP3A activity, whereas mitragynine showed stronger inhibition than speciofoline against CYP2D6 activity
