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In addition, high protein intake also increased renal flow and GFR as compared with rats fed a low-protein diet, while decreased renal vascular resistance, actions that were associated with the higher serum IGF-1 levels.83 As previously mentioned, the glomerular hemodynamic effects of IGF-1 are mainly due to increased glomerular ultrafiltration coefficient and decreased efferent arteriolar resistance

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No clear, validated mechanism