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44 Orforglipron In a phase 2, randomized, double-blind trial, daily oral orforglipron (12, 24, 36, or 45 mg) for 36 weeks led to weight reductions of 9.4–14.7% in adults with pre-obesity or obesity (without diabetes), compared to 2.3% with placebo, and showed no signs of plateau (Table 2)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 49.Xuan Y., Wang H., Yung M.M., et al