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The anti-inflammatory potential of n-3 LCPUFAs is thought to involve peroxisome proliferator-activated receptor (PPAR)-α activation and the cross-inhibition of NF-κB signaling, alongside the generation of pro-resolving lipid mediators such as resolvins, protectins, and maresins, as well as Nrf2 activation, which counteracts oxidative stress and subsequent cytokine release (Valenzuela et al., 2016)

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