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These tumor-targeting bacteria can convert prodrugs such as 5-fluorocytosine, ganciclovir, and 9-aminocamptothecin glucuronide into their active chemotherapeutic forms (5-fluorouracil, ganciclovir-3-phosphate, and 9-aminocamptothecin, respectively), potentially increasing treatment specificity and minimizing systemic toxicity
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Oxidative stress: molecular perception and transduction of signals triggering antioxidant gene defenses
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