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IL-1β, IL-6 and TNF-α gingival levels Gingival tissue samples ( n = 5/group) restricted to the maxillary molar region were collected on the 11th day and immediately frozen at -80 °C for preservation
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According to the gathered data, several signaling pathways have been implicated in Gd (III) mechanisms of toxicity, such as MAPK/ERK (mitogen-activated protein kinase/extracellular signal-regulated kinase), PI3K/Akt (phosphoinositide-3-kinase/protein kinase B), and EGFR (epidermal growth factor receptor) signaling [26,54,55,71,84,87,89,90,93], suggesting that Gd (III) interferes with the transduction of molecules involved in the regulation of inflammatory processes, and in cell metabolism, proliferation, growth, and survival
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