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Cluster of orthologous groups (COG) 0523 proteins are a distinct subfamily of the G3E P-loop NTPases that are associated with the biosynthesis of vitamin B 12 , the maturation of the Fe-dependent nitrile hydratase and a large diversity of other proteins that are often, but not always, regulated by Zur and thus become cell-abundant under conditions extreme zinc starvation (Figure 35)
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