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GLP-1 Agonists (Semaglutide, Tirzepatide) GLP-1 Agonists: Work by: Suppressing appetite and slowing digestion Weight loss: 15 to 20% of body weight Downsides: Nausea, muscle loss, rebound weight gain after stopping 5-Amino-1MQ: Works by: Blocking fat storage enzyme, improving cellular energy Weight loss: 5 to 10% of body weight (more modest but sustainable) Advantages: No appetite suppression, preserves muscle, improves metabolism Learn more about GLP-1 options: Understanding GLP-1 Supplements