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Jph203, a selective l-type amino acid transporter 1 inhibitor, induces mitochondria-dependent apoptosis in Saos2 human osteosarcoma cells

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SAHH deficiency increased intracellular S-adenosylhomocysteine (SAH) levels, leading to hypomethylation and upregulated expression of H19 gene promoter through competitive inhibition of DNMT3b, Thus promoting H19-mediated runt-related transcription factor-2 (Runx2)-dependent vascular smooth muscle cell (VSMC) osteogenic differentiation and aggravating atherosclerotic calcification