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GNE-617 inhibits the GAPDH-mediated response and PAR production, while disulfiram suppresses the TCA cycle To elucidate the mechanisms that induce the synergistic effect of combinatorial treatment, we tested metabolite changes induced by GNE-617, disulfiram, and combinatorial treatment in 3D-spheroids grown in the presence of 13 C 6 -glucose for 24 h during treatments (Supplementary Fig
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