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Structure-activity relationship for small molecule inhibitors of nicotinamide N -methyltransferase

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In further embodiments, the invention encompasses a method of treating an NNMT-expressing cancer such as glioblastoma, by administering a therapeutically effective amount of one or more cations chosen from 1c, 1f, 1l, 1m, 2j, 2k, 2l, 2m, 2aa, 1c′, 1f′, 1l′, 1m′, 2j′, 2k′, 2l′, 2m′, and 2aa′