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Though low serotonin levels may give rise to an attack, some evidence suggests that elevated serotonin levels may contribute to migraine pathology during an attack (Sakai 2008

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Our previous study (Li et al., 2017) revealed higher expression levels of NNMT in the toe extensor muscle, typically reliant on anaerobic energy metabolism for power generation, compared to the soleus muscle, typically reliant on aerobic energy metabolism