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As well as GR activity, oxidation by the three main pathways we have discussed in this review is situated within the context of glutathione synthesis and the vacuolar sequestration of a substantial part of the GSSG that is generated

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Finasteride, a 5-alpha reductase inhibitor that reduces DHT production, addresses the hormonal component of androgenetic alopecia but carries a well-documented profile of systemic side effects including sexual dysfunction, mood disturbance, and — in a subset of patients — persistent post-treatment syndrome