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The 1998 Raun characterisation paper documented that ipamorelin stimulated GH release in pigs and rats with potency comparable to GHRP-6 but without the prolactin, ACTH, cortisol, or aldosterone elevations characteristic of earlier GHRPs (PMID 9849822)

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Blood pressure typically decreases with both peptides, likely due to weight loss and improved insulin sensitivity rather than direct vascular effects