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In populations with high environmental metal exposure — including urban dwellers, industrial workers, and individuals with dental amalgam fillings — adequate glutathione levels are essential for preventing heavy metal accumulation and the neurological and systemic damage it causes

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Higher-order regions, including the prefrontal cortex, hippocampus, and amygdala, are involved in evaluating external stimuli as threats (McEwen and Gianaros, 2011), while the hypothalamus serves as a key hub of neuroendocrine and autonomic regulation, initiating and maintaining the physiological stress response (Herman et al., 2016