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IL-33, which is produced by macrophages in the skin of patients with DRESS, also attracts type 2 lymphocytes of innate immunity (ILC2 ‒ innate lymphoid cells type 2), through the ST2 receptor, promoting tissue eosinophilia.24 Th2 cells interact with dermal dendritic cells through the costimulatory molecules CD40L and CD40

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Hydration and Supplementation Hydration is essential throughout the protocol, especially during periods of microbial die-off when toxins may be released