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Consistent with this, ROS levels have been linked to the differentiation status of a number of stem cell types including ESCs and HSCs, with lower ROS driving self-renewal, and higher ROS levels being associated with differentiation ( NRF2 as a Regulator of Stem Cells In Physiological Conditions As mentioned above, NRF2 is a critical transcription factor that has been shown to regulate target genes involved in almost every facet of metabolism, ranging from maintaining the redox balance to ensuring proper protein quality control ( POMP ) ( OCT4 and NANOG and increased differentiation towards a neuronal fate (Zhou et al., 2016)
