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Evidence type: Human RCT ☐ | Observational ☐ | Animal ✔ | In vitro ✔ | Regulatory ☐ Mechanism of Action​ 5-Amino-1MQ works by blocking the NNMT enzyme , which is responsible for consuming nicotinamide and depleting NAD+ stores

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Molecular mechanism of the ichthyosis pathology of Chanarin–Dorfman syndrome: stimulation of PNPLA1-catalyzed ω- O -acylceramide production by ABHD5