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As of 2026: No Human Clinical Trials: There are no published, peer-reviewed human clinical trials investigating the combined administration of MOTS-c and Retatrutide

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Cagrilintide, an amylin analog, is studied for appetite suppression and satiety, while Retatrutide, a triple agonist (GLP-1, GIP, and glucagon), is investigated for comprehensive metabolic improvements and energy expenditure