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The structures were subsequently refined at 2.82 Å (apo wild type SnCE1), 2.21 Å (apo SnCE1 C256A) and 1.55 Å (SnCE1-SUMO1-PA) in REFMAC5 including TLS refinement 120

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Such changes remained in these same patients after 4 weeks of treatment (FENNS-4w) with the exception that the ratio of UA/Gr was completely normalized