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It is believed that they place a cationic residue near the key cysteine to ensure it is deprotonated, provide a cavity that orients H 2 O 2 for nucleophilic attack, polarize the oxygen–oxygen bond that must be split, and provide a proton donor to stabilize the hydroxide product

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Arginase II expressed in cancer-associated fibroblasts indicates tissue hypoxia and predicts poor outcome in patients with pancreatic cancer

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