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Furthermore, in a mouse model of amyloid pathology, AAV-mediated human ApoE gene expression revealed that the presence of the ApoEε4 allele exacerbated synaptic loss and Aβ deposition, while the ApoEε2 allele expression in the same model led to a reduction in brain Aβ levels (Yamazaki et al., 2019

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Seitkazina A, Yang JK, Kim S