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Firstly, we detected the expression and location of FOXO4 in mice testes by immunohistochemical staining and found that FOXO4 was rarely expressed in young mice testes, but expressed typically in the Leydig cells of aged mice (Figure 6A)
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A related analysis using the Broad Institute Connectivity Map showed that GHK's gene-activation signature overlapped with compounds known to reverse cancer-associated dysregulation
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