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While a two-year clinical trial using 300 mg per day did not show major changes in nerve function, shorter studies lasting 3 to 12 weeks found that higher doses, up to 600 mg daily, improved symptoms in people with diabetic neuropathy

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The cursory pharmacokinetic characterization of dihexa included in this study indicated that it was stable in serum, had a long circulating half-life, and penetrated the BBB