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Keywords: Glutathione, glutathione transporters, multidrug resistance-associated proteins, thiol-redox status, apoptosis, xenobiotic export, signaling, cell proliferation and differentiation Introduction Reduced glutathione (GSH) plays an important role in cell metabolism, differentiation, proliferation, and apoptosis, and as a result, disturbances in its homeostasis are implicated in the etiology and/or progression of a number of human diseases, including cancer, diseases of aging, and cardiovascular, inflammatory, immune, and neurodegenerative diseases