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(2021), it was shown that the systemic administration of mouse brain endothelial cell-derived ENPDOX to GBM-bearing mice mitigated the proliferation of GBM cells in vivo, increased their apoptosis, and prolonged the overall survival of the tested mice [24]
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Recently, several studies have shown that ferroptosis is involved in the occurrence and development of several common clinical diseases, including liver cancer 4 , nervous system disease 5 and ischemia/reperfusion injury 6
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