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This enzyme is inducible, meaning that it is not normally detected in most tissues, but its production can increase in response to certain stimuli, such as inflammation [237]

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A hallmark of ferroptotic initiation and execution is the upregulated peroxidation of phospholipid-bound polyunsaturated fatty acids (PUFAs) within cellular membranes, a process facilitated by labile iron pools (LIPs) and amplified through autocatalytic radical reactions (13,14)