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The critical role of glutathione redox homeostasis towards oxidation in ermanin-induced melanogenesis - ScienceDirect

In every metabolic pathway there is at least one reaction that is far from equilibrium because of the relatively low activity of the enzyme involved

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Increased Metabolic Demand- Some genetic conditions can impair the body’s ability to transport, store, or utilize thiamine, which can lead to a functional deficiency even if dietary intake is adequate