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Presented for research literature review only Silberzahn P et al

Pigmentation & Melasma

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Upon transferring wild-type and Gpx4-deficient T cells into the mouse model, while wild-type T cells proliferated normally post transplantation, Gpx4-deficient CD4+ and CD8+ T cells rapidly decayed within 7 days, undergoing ferroptosis, underscoring the innate role of Gpx4 in the proliferation and survival of CD4+ and CD8+ T cells [83]