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Candida forces macrophage energy exhaustion through competitive glucose consumption, activating AMPK-Bcl-2-associated X protein/Bcl-2 homologous antagonist killer (Bax/Bak)-dependent apoptosis (125), while Yersinia pseudotuberculosis conversely activates AMPK to inhibit apoptosis, maintaining host cell survival to promote intracellular replication (126)
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Even so, environmental and lifestyle factors remain powerful determinants of long-term cognitive health and neural resilience
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