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189 In contrast, from a prophylactic approach, another research group proposed what they deemed a cost-effective approach of yearly injections of 1000 μg of vitamin B12 to every patient on metformin to reduce the risk of deficiency and also stated that this could remove the requirement for annual screening, though this has not been empirically tested

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Sobo’s Stamford clinic uses LC/MS (liquid chromatography-mass spectrometry) methodology, avoiding cross-reactivity errors common with immunoassay testing