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Myosin light chain kinase is central to smooth muscle contraction and required for gastrointestinal motility in mice

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Current anti-obesity pharmacotherapy includes 5 FDA-approved medications: orlistat, phentermine-topiramate, naltrexone-bupropion, liraglutide, and semaglutide (Table 2), as well as phentermine, which is approved only for short term use