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Resveratrol in red wine, quercetin in apples, and catechins in green tea activate cellular stress response pathways, notably the Nrf2/ARE pathway, leading to increased production of endogenous antioxidants and detoxification enzymes

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In our GBM models, depletion of the cellular NADH pool resulting from the combined treatment of sertraline and chloroquine might enhance the sensitivity of resistant GBM cells to chloroquine by increasing the availability of the NADH-binding pocket to exert its function