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While established epigenetic clocks—such as Horvath’s pan-tissue clock, Hannum’s DNAm age, Levine’s PhenoAge, GrimAge, and DunedinPACE—remain key benchmarks in the field, the TruAge Index was selected for this study due to its validated performance in saliva samples, ease of use, and robust responsiveness to biological age-modifying interventions

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No finalized large-scale human clinical trials are published that demonstrate safety and efficacy in humans

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