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There are significant changes in hepatic nutrient metabolism in pregnant women compared with nonpregnant women, including increases in glucose metabolism, and lipid and cholesterol metabolism, protein synthesis, and a decrease AA catabolism ( Figure 2 )

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These findings are further supported by earlier reports showing that the IC₅₀ of cisplatin in mouse fibroblasts exceeds ~ 100 μM, whereas in human fibroblasts during logarithmic growth, it is approximately 15 μM 62