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It is when we see moderate to high numbers of these oxidant changes in RBCs (very large or multiple Heinz bodies in cats, eccentrocytes with Heinz bodies in a dog, eccentrocytes or Heinz bodies in a horse) that we attribute an anemia to oxidative injury
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However, more recent findings suggest that cisplatin causes a permanent reduction in GFR (Dentino et al., 1978
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