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Additionally, reperfusion ischemia is associated with ATP depletion, elevated intracellular calcium levels [ 85 ] , increased production of ROS, and reduced activity of antioxidant enzymes such as SOD, CAT, and GP X [ 86 , 87 ]

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7 Conclusions and perspectives In recent years, with the increasing exploration of the intestinal microenvironment, there is growing evidence that dysbiosis of the gut microbiota and disorders of iron metabolism are closely associated with the onset and progression of IBD