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Increased mtDNA CR mutations have also been detected in peripheral blood DNA and in lymphoblastoid cell DNAs of AD and DSAD patients, and distinctive somatic mtDNA mutations are seen in AD and DSAD DNA from brain and cells

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Macrophage studies demonstrate that GHK-Cu administration shifts these cells from a pro-inflammatory M1 phenotype to a tissue-repairing M2 phenotype, increasing their production of growth factors including vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) by 40-60%