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Examples of non-hydrogen substituents includes halogen, C1-4 alkyl, halogen-substituted C1-4 alkyl, NR 9 R 10 , NR 11 R 12 , and CN

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By separating the lipolytic C-terminal region, researchers produced a compound with concentrated fat-metabolism activity and a significantly reduced side-effect profile compared to recombinant GH — particularly with respect to insulin sensitivity and IGF-1 axis stimulation, which are primary concerns with full GH administration in research models