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Selank was developed at the Institute of Molecular Genetics of the Russian Academy of Sciences and is based on the naturally occurring immunomodulatory peptide tuftsin (Thr-Lys-Pro-Arg, corresponding to residues 289-292 of the IgG heavy chain) with a C-terminal Pro-Gly-Pro extension derived from the proline-rich peptide family that enhances metabolic stability and CNS penetration