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Immune-Modulating Properties of NAC It has been demonstrated that NAC can change the redox balance towards reduced status inside neutrophils by replenishing reduced glutathione (GSH), which suppresses NF-κB activation at concentrations of 10mM or more, resulting in modulation of cytokine production and chemotactic signals.28 Moreover, neutrophils from healthy volunteers taking NAC (600 mg daily) for 14 days showed lower rates of oxidative burst and chemotaxis

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