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Whereas Xpd TTD/TTD mice generally show less exploratory behavior compared to wildtype littermates, FOXO4-DRI treated animals were noticeably more active (Fig

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In T2DM, chronic hyperglycemia leads to the downregulation of crucial mitochondrial enzymes, such as pyruvate carboxylase, citrate synthase, and reduced nicotinamide adenine dinucleotide (NADH) dehydrogenase, which are necessary for glucose-stimulated insulin secretion (GSIS) [21,22]

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