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In the absence of known physiological substrates, hydroxyl-ethyl disulfide (HED), and DHA are often used to characterize the activity of recombinant GSTs as well as glutaredoxins, but it turns out that most glutathione-dependent oxidoreductases display such activities with very similar kinetic parameters (Table 5)

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This information means exposing cancer cells to ionizing radiation before pharmacotherapy may result in chemotherapy resistance