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Of the 67 included studies, randomized controlled trials were the most common study design (n = 34), followed by cohort studies (n = 16), preimplementation/postimplementation studies (n = 14), and cross-sectional studies (n = 3)

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Interference with JAK-STAT signaling in known not to affect the viability of senescent cells(Xu et al., 2015) and we have previously observed similar effects for NFκB and p53 inhibition(Freund et al., 2011