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In addition, when the storage and catabolic capacity of adipose tissue is exceeded due to excess lipids, lipids can be deposited in non-adipose tissues such as the liver and kidneys, causing lipotoxicity in these target organs, leading to insulin resistance, generation of reactive oxygen species (ROS), and endoplasmic reticulum stress, resulting in cellular damage and even death, which could result in the onset of DKD ( Insufficient insulin secretion or failure to utilize insulin effectively leads to glucose and lipid accumulation

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BCG therapy down-regulates HLA-I on malignant cells to subvert antitumor immune responses in bladder cancer[J]