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On the one hand, SQOR activation appears beneficial in ischemic, hypoxic injury ( 2 S activates the NRF2–SQOR pathway, upregulating SQOR and NRF2 and inducing autophagy as well as antioxidant genes (e.g., NQO1 , CSE )

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There’s even evidence it can help counter the effects of fatty liver and protect heart and brain health in the long term