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Lin Z, Zou S, Wen K
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Domvanalimab (an anti-TIGIT antibody) was engineered as an Fc-silent antibody lacking Fc effector function to avoid inducing ADCC (antibody-dependent cellular cytotoxicity) and thereby to preserve peripheral Tregs that are critical for maintaining immune homeostasis, which may potentially reduce the risk of autoimmune toxicities compared with Fc-enabled antibodies [461]
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