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THERAPEUTIC STRATEGIES FOR WD Current pharmacological approaches Current treatment approaches aim to reduce systemic copper burden either by limiting intestinal copper absorption through zinc-induced metallothionein-mediated sequestration of copper within enterocytes or by enhancing urinary copper excretion using chelators such as D-penicillamine and trientine [4]

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I have bad memory loss, depression, aches and pain and bad headaches Estella Reply March 31, 2024 I stopped tamoxifen 6days ago after being on it for 5months I was on letrozole for 2.5 yrs but the joint pain became to much .when I first started Tamoxifen I got a bit of anxiety and loss of appetite about 4 weeks into taking then it settled then a week ago the anxiety and nausea became unbearable so I stopped I have oncologist appointment in 2 weeks so will discuss either reduced dose or a different AI Kim Reply July 12, 2023 Hi I’m Sandy