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Researchers are also exploring DSIP’s effects on individuals with pronounced pain episodes and major depressive disorder, where sleep disturbances are common

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Importantly, Clusterin/ApoJ is a key component of brain-derived lipoproteins and is therefore critical to brain lipid transport and homeostasis (Merrill et al., 2023), and also plays important roles in immune response modulation, cell death and survival, oxidative stress, and proteotoxic stress (e.g., Aβ build-up and toxicity